Wednesday, February 20, 2008

Your OWN or your FAMILY's are always the BEST!

Use your OWN or a SIBLING’S cord blood stem cells and achieve CURE or REMISSION!

Data from a retrospective review of blood disorder patients treated with stem cells from their own cord blood (autologous transplant) or from the cord blood of a sibling (allogeneic-related transplant), presented at the American Society for Blood and Marrow Treatment (ASBMT) annual meeting showed that the majority of the patients were cured or achieved remission from their disease. Moreover, low risk of transplant-related complications with genetically-Related cord blood stem cells was seen.

Dr. Jennifer Willert, senior attending transplant physician and clinical professor at Rady Children's Hospital, University of California - San Diego, and lead author of this study said that “we now have important insights into the ability of transplant physicians to achieve successful outcomes using an individual's own cord blood to treat an environmentally-triggered blood disease or cord blood from a family member to treat certain genetic blood disorders and inherited bone marrow failure syndromes (IBMFs). Furthermore, the use of genetically-related cord blood may reduce the rate of mortality as well as the risk of treatment-related complications".

The analysis examined transplant recipient data from 16 cases of nonmalignant blood disorders. Four of the patients were infused with their own cord blood stem cells to treat aplastic anemia, an acquired condition. Twelve patients were transplanted with cord blood stem cells of a sibling for a range of inherited conditions including, thalassemia, sickle cell anemia, Fanconi anemia and Hurler syndrome. The review showed that two-thirds of the patients (10) are either cured or in remission, including half of the patients treated with their own cord blood. Three patients died of complications unrelated to their cord blood transplant; one patient experienced a relapse; and the outcomes status of two patients is not known. All 16 cord blood collections were processed and cryo-preserved at Cord Blood Registry and were viable for transplant when requested. The average storage time prior to use was about 27 months; however, one child's collection was stored for nine and half years and used to successfully cure that child's aplastic anemia (autologous use)!


Advantages of Genetically-Related Cord Blood Use in Transplantation

According to previously published data, transplantation of genetically-related umbilical cord blood has demonstrated clinical advantages over bone marrow, peripheral blood and unrelated umbilical cord blood. Since cord blood stem cells are immunologically younger than other "adult" stem cell sources, they demonstrate more versatility and flexibility when used in transplantation. Stem cell transplants from genetically-related sources (those from an immediate family member) result in better treatment outcomes than transplants from an unrelated donor and are associated with less frequent and less severe graft-vs.-host disease, a complication that occurs when the donor cells attack different parts of the body. Cord blood is rapidly becoming a preferred stem cell source in transplant therapy (a standard treatment in children's BMT already), with more than 10,000 cord blood transplants performed worldwide to-date.

Dr Willert said: "This study is relevant to any expectant parent considering whether or not to privately bank cord blood stem cells, Individuals who have access to their own cord blood stem cells, as well as a sibling's, have the best chance of treating a blood disorder that develops."

It is really not much to talk about here; the study really speaks for itself! The final comments of one of the authors say it all. Little miracles are hidden in our OWN veins!




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